Tumorigenicity of IV-Nitrosohexamethyleneimine1
نویسنده
چکیده
A new carcinogen, W-nitrosohexamethyleneimine (W-nitrosoperhydroazepine), was synthesized and given to rats of both sexes. The incidence of mixed malignant liver cell carcinomas and endothelial sarcomas was virtually 100% when the drug was given at 200 mg/liter for 8 weeks, while benign and malig nant epitheliomas of the tongue or esophagus occurred in about 30%. When the drug concentration was 50 mg/liter given con tinuously over the life-span of the animals, the incidence pat tern of tumors in liver and upper alimentary tract was re versed. The possible relevance of the types and distribution of these cancers to interpretations of the mechanism of action is discussed.
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تاریخ انتشار 2006